Publications

Patsy, Marisa, Kyle Ge, Alastair Khodabukus, and Nenad Bursac. “Development and modeling of cardiac autonomic innervation.” Nature Cardiovascular Research 4, no. 12 (December 2025): 1598–1615. https://doi.org/10.1038/s44161-025-00746-7.

Helfer, Abbigail, Tara Sheehan, and Nenad Bursac. “Abstract 4369523: A Novel Bioreactor to Model Time-Varying Mechanical Preload and Afterload in Engineered Cardiac Tissues.” In Circulation, Vol. 152. Ovid Technologies (Wolters Kluwer Health), 2025. https://doi.org/10.1161/circ.152.suppl_3.4369523.

Siu, Yiu Yan, Yongwu Li, Anna Tornatore, Bianca Wertheimer, and Nenad Bursac. “Abstract 4358648: Prokaryotic Voltage-Gated Sodium Channel (BacNav) Gene Therapy Restores Contractile and Electrical Function in a Rat Model of Chronic Ischemia-Reperfusion Heart Failure.” In Circulation, Vol. 152. Ovid Technologies (Wolters Kluwer Health), 2025. https://doi.org/10.1161/circ.152.suppl_3.4358648.

Silkstone, Dylan, Alastair Khodabukus, Wanyu Zhang, and Nenad Bursac. “Abstract 4359395: Cardiac Function is Preserved in a Tissue-Engineered Model of LGMD2B.” In Circulation, Vol. 152. Ovid Technologies (Wolters Kluwer Health), 2025. https://doi.org/10.1161/circ.152.suppl_3.4359395.

Patsy, Marisa, Evan Abramov, Nora Taylor, Kyle Ge, and Nenad Bursac. “Abstract 4364390: Development of an In Vitro Model of Functionally Innervated Human Myocardium.” In Circulation, Vol. 152. Ovid Technologies (Wolters Kluwer Health), 2025. https://doi.org/10.1161/circ.152.suppl_3.4364390.

Pronobis, Mira I., Sophia DeLuca, Siyun Lee, Lucas Garcia, Jianhong Ou, Nenad Bursac, and Kenneth D. Poss. “Ddx61-enriched condensates refine heart regeneration programs.” Nat Commun 16, no. 1 (October 9, 2025): 8992. https://doi.org/10.1038/s41467-025-64026-5.

Wolfson, David W., Joshua A. Hull, Yongwu Li, Trevor J. Gonzalez, Mourya D. Jayaram, Garth W. Devlin, Valentina Cigliola, et al. “Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium.” ELife 14 (September 12, 2025). https://doi.org/10.7554/elife.107148.3.

Strash, Nicholas, Marisa Patsy, Sophia DeLuca, Abbigail Helfer, Xixian Jiang, Tianyu Wu, and Nenad Bursac. “Effects of Pharmacological Polyploidization in Human iPSC-Derived Cardiomyocytes.” Journal of the American Heart Association 14, no. 17 (September 2025): e040497. https://doi.org/10.1161/jaha.124.040497.

Wu, Tianyu, Nicole G. Z. Tee, Yiu Yan Siu, Anna Tornatore, Abhishek Bhattacharjee, James Koconis, Sze Jie Loo, et al. “BacNa_v Gene Therapy Improves Function of Infarcted Engineered Human Myocardium and NHPs.” Circulation Research 137, no. 6 (August 2025): 899–901. https://doi.org/10.1161/circresaha.125.326570.

Broer, Torie, Nick Tsintolas, Stewart Hammond, Abbigail Helfer, Joonbum Lee, Karly Purkey, Sophia DeLuca, Alastair Khodabukus, and Nenad Bursac. “Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function.” Advanced Healthcare Materials 14, no. 12 (May 2025): e2404695. https://doi.org/10.1002/adhm.202404695.

Fuchs, Michaela A. A., Emily J. Burke, Nejla Latic, Susan L. Murray, Hanjun Li, Matthew A. Sparks, Dennis Abraham, et al. “Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Kidney Int 107, no. 5 (May 2025): 852–68. https://doi.org/10.1016/j.kint.2025.01.024.

DeLuca, Sophia, Nicholas Strash, Yifan Chen, Marisa Patsy, Ashley Myers, Libertad Tejeda, Sarah Broders, Amber Miranda, Xixian Jiang, and Nenad Bursac. “Engineered Cardiac Tissues as a Platform for CRISPR-Based Mitogen Discovery.” Advanced Healthcare Materials 14, no. 1 (January 2025): e2402201. https://doi.org/10.1002/adhm.202402201.

Helfer, A., N. Strash, M. Patsy, and N. Bursac. “Crossbow Bioreactors for Studying the Effects of Time-Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues.” Advanced Functional Materials, January 1, 2025. https://doi.org/10.1002/adfm.202519601.

Li, Hanjun, Ilya Shadrin, Abbigail Helfer, Karen Heman, Lingjun Rao, Caroline Curtis, Gregory M. Palmer, and Nenad Bursac. “In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.” Acta Biomater, November 10, 2024. https://doi.org/10.1016/j.actbio.2024.11.014.

Broer, Torie, Nick Tsintolas, Karly Purkey, Stewart Hammond, Sophia DeLuca, Tianyu Wu, Ishika Gupta, Alastair Khodabukus, and Nenad Bursac. “Engineered myovascular tissues for studies of endothelial/satellite cell interactions.” Acta Biomaterialia 188 (October 2024): 65–78. https://doi.org/10.1016/j.actbio.2024.09.020.

Khodabukus, Alastair, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D. Fralish, Megan E. Kondash, George A. Truskey, Timothy R. Koves, and Nenad Bursac. “Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy.” Adv Sci (Weinh) 11, no. 31 (August 2024): e2400188. https://doi.org/10.1002/advs.202400188.

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Tianyu Wu, Abbigail Helfer, Jacob Scherba, et al. “Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium.” Science Advances 10, no. 4 (January 2024): eadh2598. https://doi.org/10.1126/sciadv.adh2598.

Fuchs, Michaela A., Emily J. Burke, Nejla Latic, Susan Murray, Hanjun Li, Matthew Sparks, Dennis Abraham, et al. “Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Res Sq, December 23, 2023. https://doi.org/10.21203/rs.3.rs-3705543/v1.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 14, no. 1 (November 16, 2023): 7411. https://doi.org/10.1038/s41467-023-43260-9.

Needs, Daniel, Tianyu Wu, Hung X. Nguyen, Craig S. Henriquez, and Nenad Bursac. “Prokaryotic voltage-gated sodium channels are more effective than endogenous Na_v1.5 channels in rescuing cardiac action potential conduction: an in silico study.” American Journal of Physiology. Heart and Circulatory Physiology 325, no. 5 (November 2023): H1178–92. https://doi.org/10.1152/ajpheart.00287.2023.

Chakraborty, Archan, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, et al. “Conserved chamber-specific polyploidy maintains heart function in Drosophila.” Development 150, no. 16 (August 15, 2023). https://doi.org/10.1242/dev.201896.

Wu, Tianyu, Binjie Li, James Koconis, Abhishek Bhattacharjee, Lei Ye, and Nenad Bursac. “Abstract P2164: Expression Of Engineered Bacterial Sodium Channel Improves Cardiomyocyte Contractility.” In Circulation Research, Vol. 133. Ovid Technologies (Wolters Kluwer Health), 2023. https://doi.org/10.1161/res.133.suppl_1.p2164.

Zhang, Qiao, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, and George A. Truskey. “Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus.” J Am Heart Assoc 12, no. 12 (June 20, 2023): e029390. https://doi.org/10.1161/JAHA.123.029390.

Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.

Sitton, Madeleine J., Alastair Khodabukus, Joel D. Bohning, Nenad Bursac, and Charles A. Gersbach. “Modeling Gene Editing Outcomes in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy.” In MOLECULAR THERAPY, 31:65–65, 2023.