Publications

Broer, Torie, Nick Tsintolas, Stewart Hammond, Abbigail Helfer, Joonbum Lee, Karly Purkey, Sophia DeLuca, Alastair Khodabukus, and Nenad Bursac. “Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function.” Advanced Healthcare Materials 14, no. 12 (May 2025): e2404695. https://doi.org/10.1002/adhm.202404695.

Fuchs, Michaela A. A., Emily J. Burke, Nejla Latic, Susan L. Murray, Hanjun Li, Matthew A. Sparks, Dennis Abraham, et al. “Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Kidney Int 107, no. 5 (May 2025): 852–68. https://doi.org/10.1016/j.kint.2025.01.024.

Wolfson, David W., Joshua A. Hull, Yongwu Li, Trevor J. Gonzalez, Mourya D. Jayaram, Garth W. Devlin, Valentina Cigliola, et al. “Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium.” Cold Spring Harbor Laboratory, May 1, 2025. https://doi.org/10.1101/2025.04.28.651096.

DeLuca, Sophia, Nicholas Strash, Yifan Chen, Marisa Patsy, Ashley Myers, Libertad Tejeda, Sarah Broders, Amber Miranda, Xixian Jiang, and Nenad Bursac. “Engineered Cardiac Tissues as a Platform for CRISPR-Based Mitogen Discovery.” Advanced Healthcare Materials 14, no. 1 (January 2025): e2402201. https://doi.org/10.1002/adhm.202402201.

Li, Hanjun, Ilya Shadrin, Abbigail Helfer, Karen Heman, Lingjun Rao, Caroline Curtis, Gregory M. Palmer, and Nenad Bursac. “In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.” Acta Biomater, November 10, 2024. https://doi.org/10.1016/j.actbio.2024.11.014.

Broer, Torie, Nick Tsintolas, Karly Purkey, Stewart Hammond, Sophia DeLuca, Tianyu Wu, Ishika Gupta, Alastair Khodabukus, and Nenad Bursac. “Engineered Myovascular Tissues for Studies of Endothelial/Satellite Cell Interactions.” Acta Biomaterialia, September 2024, S1742-7061(24)00536-1. https://doi.org/10.1016/j.actbio.2024.09.020.

Khodabukus, Alastair, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D. Fralish, Megan E. Kondash, George A. Truskey, Timothy R. Koves, and Nenad Bursac. “Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy.” Adv Sci (Weinh) 11, no. 31 (August 2024): e2400188. https://doi.org/10.1002/advs.202400188.

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Tianyu Wu, Abbigail Helfer, Jacob Scherba, et al. “Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium.” Science Advances 10, no. 4 (January 2024): eadh2598. https://doi.org/10.1126/sciadv.adh2598.

Fuchs, Michaela A., Emily J. Burke, Nejla Latic, Susan Murray, Hanjun Li, Matthew Sparks, Dennis Abraham, et al. “Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Res Sq, December 23, 2023. https://doi.org/10.21203/rs.3.rs-3705543/v1.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 14, no. 1 (November 16, 2023): 7411. https://doi.org/10.1038/s41467-023-43260-9.

Needs, Daniel, Tianyu Wu, Hung X. Nguyen, Craig S. Henriquez, and Nenad Bursac. “Prokaryotic voltage-gated sodium channels are more effective than endogenous Na_v1.5 channels in rescuing cardiac action potential conduction: an in silico study.” American Journal of Physiology. Heart and Circulatory Physiology 325, no. 5 (November 2023): H1178–92. https://doi.org/10.1152/ajpheart.00287.2023.

Chakraborty, Archan, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, et al. “Conserved chamber-specific polyploidy maintains heart function in Drosophila.” Development 150, no. 16 (August 15, 2023). https://doi.org/10.1242/dev.201896.

Wu, Tianyu, Binjie Li, James Koconis, Abhishek Bhattacharjee, Lei Ye, and Nenad Bursac. “Abstract P2164: Expression Of Engineered Bacterial Sodium Channel Improves Cardiomyocyte Contractility.” In Circulation Research, Vol. 133. Ovid Technologies (Wolters Kluwer Health), 2023. https://doi.org/10.1161/res.133.suppl_1.p2164.

Zhang, Qiao, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, and George A. Truskey. “Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus.” J Am Heart Assoc 12, no. 12 (June 20, 2023): e029390. https://doi.org/10.1161/JAHA.123.029390.

Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.

Sitton, Madeleine J., Alastair Khodabukus, Joel D. Bohning, Nenad Bursac, and Charles A. Gersbach. “Modeling Gene Editing Outcomes in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy.” In MOLECULAR THERAPY, 31:65–65, 2023.

Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.

Scherba, Jacob C., Ravi Karra, Joseph W. Turek, and Nenad Bursac. “Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.” J Thorac Cardiovasc Surg 164, no. 6 (December 2022): 2013–18. https://doi.org/10.1016/j.jtcvs.2022.02.028.

Khodabukus, Alastair, Tyler Guyer, Axel C. Moore, Molly M. Stevens, Robert E. Guldberg, and Nenad Bursac. “Translating musculoskeletal bioengineering into tissue regeneration therapies.” Science Translational Medicine 14, no. 666 (October 2022): eabn9074. https://doi.org/10.1126/scitranslmed.abn9074.

Scherba, Jacob C., Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, and Carolyn Glass. “BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.” Sci Rep 12, no. 1 (May 17, 2022): 7996. https://doi.org/10.1038/s41598-022-11829-x.

Wang, Jason, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran, Yu Xiang, Alastair Khodabukus, Yarui Diao, and Nenad Bursac. “Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.” Biomaterials 284 (May 2022): 121508. https://doi.org/10.1016/j.biomaterials.2022.121508.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 13, no. 1 (February 2, 2022): 620. https://doi.org/10.1038/s41467-022-28251-6.

Janbandhu, Vaibhao, Vikram Tallapragada, Ralph Patrick, Yanzhen Li, Dhanushi Abeygunawardena, David T. Humphreys, Ella M. M. A. Martin, et al. “Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.” Cell Stem Cell 29, no. 2 (February 2022): 281-297.e12. https://doi.org/10.1016/j.stem.2021.10.009.

Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Yifan Chen, Jacob Scherba, Mehul Jain, Ramona Naseri, Tianyu Wu, and Nenad Bursac. “BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.28.482357.

Wu, Tianyu, Sze-Jie Loo, Yu Gao, Jun-Hua Luo, Liping Su, Nicole Gee-Zhi Tee, Lei Ye, and Nenad Bursac. “Engineered Bacterial Sodium Channel Gene Therapy Prevents Contractile Deficit and Reduces Ventricular Arrhythmias in a Non-Human Primate Model of Myocardial Infarction.” In CIRCULATION, Vol. 146, 2022.