Publications

2024

Khodabukus, Alastair, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler, Zachary D. Fralish, Megan E. Kondash, George A. Truskey, Timothy R. Koves, and Nenad Bursac. “Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy.” Adv Sci (Weinh), June 17, 2024, e2400188. https://doi.org/10.1002/advs.202400188.

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Tianyu Wu, Abbigail Helfer, Jacob Scherba, et al. “Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium.” Science Advances 10, no. 4 (January 2024): eadh2598. https://doi.org/10.1126/sciadv.adh2598.

2023

Fuchs, Michaela A., Emily J. Burke, Nejla Latic, Susan Murray, Hanjun Li, Matthew Sparks, Dennis Abraham, et al. “Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Res Sq, December 23, 2023. https://doi.org/10.21203/rs.3.rs-3705543/v1.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 14, no. 1 (November 16, 2023): 7411. https://doi.org/10.1038/s41467-023-43260-9.

Needs, Daniel, Tianyu Wu, Hung X. Nguyen, Craig S. Henriquez, and Nenad Bursac. “Prokaryotic voltage-gated sodium channels are more effective than endogenous Nav1.5 channels in rescuing cardiac action potential conduction: an in silico study.” American Journal of Physiology. Heart and Circulatory Physiology 325, no. 5 (November 2023): H1178–92. https://doi.org/10.1152/ajpheart.00287.2023.

Chakraborty, Archan, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, et al. “Conserved chamber-specific polyploidy maintains heart function in Drosophila.” Development 150, no. 16 (August 15, 2023). https://doi.org/10.1242/dev.201896.

Wu, Tianyu, Binjie Li, James Koconis, Abhishek Bhattacharjee, Lei Ye, and Nenad Bursac. “Abstract P2164: Expression Of Engineered Bacterial Sodium Channel Improves Cardiomyocyte Contractility.” In Circulation Research, Vol. 133. Ovid Technologies (Wolters Kluwer Health), 2023. https://doi.org/10.1161/res.133.suppl_1.p2164.

Zhang, Qiao, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, and George A. Truskey. “Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus.” J Am Heart Assoc 12, no. 12 (June 20, 2023): e029390. https://doi.org/10.1161/JAHA.123.029390.

Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.

Sitton, Madeleine J., Alastair Khodabukus, Joel D. Bohning, Nenad Bursac, and Charles A. Gersbach. “Modeling Gene Editing Outcomes in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy.” In MOLECULAR THERAPY, 31:65–65, 2023.

2022

Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.

Scherba, Jacob C., Ravi Karra, Joseph W. Turek, and Nenad Bursac. “Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.” J Thorac Cardiovasc Surg 164, no. 6 (December 2022): 2013–18. https://doi.org/10.1016/j.jtcvs.2022.02.028.

Khodabukus, Alastair, Tyler Guyer, Axel C. Moore, Molly M. Stevens, Robert E. Guldberg, and Nenad Bursac. “Translating musculoskeletal bioengineering into tissue regeneration therapies.” Science Translational Medicine 14, no. 666 (October 2022): eabn9074. https://doi.org/10.1126/scitranslmed.abn9074.

Scherba, Jacob C., Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, and Carolyn Glass. “BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.” Sci Rep 12, no. 1 (May 17, 2022): 7996. https://doi.org/10.1038/s41598-022-11829-x.

Wang, Jason, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran, Yu Xiang, Alastair Khodabukus, Yarui Diao, and Nenad Bursac. “Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.” Biomaterials 284 (May 2022): 121508. https://doi.org/10.1016/j.biomaterials.2022.121508.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 13, no. 1 (February 2, 2022): 620. https://doi.org/10.1038/s41467-022-28251-6.

Janbandhu, Vaibhao, Vikram Tallapragada, Ralph Patrick, Yanzhen Li, Dhanushi Abeygunawardena, David T. Humphreys, Ella M. M. A. Martin, et al. “Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.” Cell Stem Cell 29, no. 2 (February 2022): 281-297.e12. https://doi.org/10.1016/j.stem.2021.10.009.

Dzirasa, Kafui, Elizabeth Ransey, Kirill Chesnov, Elias Wisdom, Ryan Bowman, Tatiana Rodriguez, Elise Adamson, et al. “Long-Term Precision Editing of Neural Circuits Using Engineered Gap Junction Hemichannels.” In BIOLOGICAL PSYCHIATRY, 91:S14–15, 2022.

Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Yifan Chen, Jacob Scherba, Mehul Jain, Ramona Naseri, Tianyu Wu, and Nenad Bursac. “BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.28.482357.

Wu, Tianyu, Sze-Jie Loo, Yu Gao, Jun-Hua Luo, Liping Su, Nicole Gee-Zhi Tee, Lei Ye, and Nenad Bursac. “Engineered Bacterial Sodium Channel Gene Therapy Prevents Contractile Deficit and Reduces Ventricular Arrhythmias in a Non-Human Primate Model of Myocardial Infarction.” In CIRCULATION, Vol. 146, 2022.

DeLuca, Sophia, and Nenad Bursac. “CRISPR Library Screening in Cultured Cardiomyocytes.” Methods in Molecular Biology (Clifton, N.J.) 2485 (January 2022): 1–13. https://doi.org/10.1007/978-1-0716-2261-2_1.

Sitton, Madeleine J., Alastair Khodabukus, K Tyler McCullough, Nenad Bursac, and Charles A. Gersbach. “CRISPR Genome Editing in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy.” In MOLECULAR THERAPY, 30:500–500, 2022.

Vann, Christopher G., Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, and Virginia B. Kraus. “Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle.” Front Physiol 13 (2022): 937899. https://doi.org/10.3389/fphys.2022.937899.

Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.

2021

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Soon Chul Heo, Ryne Gorsuch, and Nenad Bursac. “Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.” ELife 10 (October 2021): e65512. https://doi.org/10.7554/elife.65512.