Striated muscle function, regeneration, and repair.

TitleStriated muscle function, regeneration, and repair.
Publication TypeJournal Article
Year of Publication2016
AuthorsShadrin, IY, Khodabukus, A, and Bursac, N
JournalCellular and Molecular Life Sciences
Volume73
Issue22
Start Page4175
Pagination4175 - 4202
Date Published11/2016
Abstract

As the only striated muscle tissues in the body, skeletal and cardiac muscle share numerous structural and functional characteristics, while exhibiting vastly different size and regenerative potential. Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging. In contrast, the mammalian heart loses its regenerative capacity shortly after birth, leaving it susceptible to permanent damage by acute injury or chronic disease. In this review, we compare and contrast the physiology and regenerative potential of native skeletal and cardiac muscles, mechanisms underlying striated muscle dysfunction, and bioengineering strategies to treat muscle disorders. We focus on different sources for cellular therapy, biomaterials to augment the endogenous regenerative response, and progress in engineering and application of mature striated muscle tissues in vitro and in vivo. Finally, we discuss the challenges and perspectives in translating muscle bioengineering strategies to clinical practice.

DOI10.1007/s00018-016-2285-z
Short TitleCellular and Molecular Life Sciences