Professor of Biomedical Engineering
My research interests include adult and embryonic stem cell therapies for heart and muscle disease, cardiac and skeletal muscle tissue engineering, cardiac electrophysiology and arrhythmias, genetic modifications of stem and somatic cells, and micropatterning of proteins and hydrogels.
My primary responsibilities involve animal surgeries: coronary artery ligation, implant engineered cardiac tissue patch onto heart, skeletal muscle injury and repair, engineered tissue window chamber implantation, and following implantation studies with biochemical and molecular biology analysis.
I am the lab manager for the Bursac Lab, and I also assist lab members with molecular biology and cell culture.
I work on engineered cardiac tissues derived from human pluripotent stem cells.
My project is engineering biomimetic, highly-functional skeletal muscle tissues capable of self-repair in vitro and survival, vascularization, and maturation in vivo
I work on developing more physiologically relevant tissue engineered skeletal muscle to study both healthy and diseased muscle physiology in human and rat cells.
I am interested in the fidelity of the electrical system and the role of fibroblasts in cardiac regeneration.
My current project is focused on generating functional skeletal muscle bundles with cells derived from human pluripotent stem cells for drug development, disease modeling and implantation therapies.
I am studying the regenerative capacity of tissue-engineered skeletal muscle in vitro
During my first year, I will explore the potential of cardiac patches derived from human embryonic and induced pluripotent stem cells to repair damaged tissue after myocardial infarction.
I am studying how mechanical forces regulate the recruitment and membrane distribution of ion channels.
My research focuses on postnatal hypertrophy and maturation of cardiomyocytes in engineered 3D tissues.
I study how different cardiac fibroblast phenotypes affect the structure and function of engineered 3D tissues.
I work on designing and engineering electrically active primary human cells with customized electrophysiological phenotypes for cardiac repair.
My project is focused on differentiating cardiomyocytes from human stem cells, and assembling them into highly functional 3D cardiac patches.
I am exploring methods to improve the regenerative capacity of engineered tissues derived from human skeletal muscle cells