Professor of Biomedical Engineering
Embryonic and adult stem cell therapies for heart and muscle disease; cardiac and skeletal muscle tissue engineering; cardiac electrophysiology and arrhythmias; genetic modifications of stem and somatic cells; micropatterning of proteins and hydrogels.
I will be performing rodent surgeries to support cardiac and skeletal muscle studies.
I am working on human engineered skeletal and cardiac muscle for organ-on-chip studies.
Associate in research
I work on human skeletal muscle tissue engineering.
I am the lab manager for the Bursac Lab, and I also assist lab members with molecular biology and cell culture.
I work on developing more physiologically relevant tissue engineered skeletal muscle to study both healthy and diseased muscle physiology in human and rat cells.
I study the mechanisms of ion channel trafficking in reponse to biomechanical cues.
I work on designing and engineering electrically active primary human cells with customized electrophysiological phenotypes for cardiac repair.
I am interested in the fidelity of the electrical system and the role of fibroblasts in cardiac regeneration.
My current project is focused on generating functional skeletal muscle bundles with cells derived from human pluripotent stem cells for drug development, disease modeling and implantation therapies.
I am studying how mechanical forces regulate the recruitment and membrane distribution of ion channels.
I am studying how the presence of immune cells affects the development and function of engineered skeletal muscle tissue.
I work on human cardiac tissue engineering from pluripotent stem cells, and gene editing.
I am studying how disease-induced changes in fibroblast phenotype alter the electrical and mechanical function of 3D engineered cardiac tissues and determine the underlying molecular mechanisms.
I am currently interested in studying the role of polyploidy in the context of proliferation and maturation of human iPSC-derived cardiomyocytes.
I am exploring methods to improve the regenerative capacity of engineered tissues derived from human skeletal muscle cells.
I am interested in developing tissue-engineered skeletal muscle models of congenital human disease to study diseased physiology and test preclinical treatments.