Distilling complexity to advance cardiac tissue engineering.

TitleDistilling complexity to advance cardiac tissue engineering.
Publication TypeJournal Article
Year of Publication2016
AuthorsOgle, BM, Bursac, N, Domian, I, Huang, NF, Menasché, P, Murry, CE, Pruitt, B, Radisic, M, Wu, JC, Wu, SM, Zhang, J, Zimmermann, W-H, and Vunjak-Novakovic, G
JournalScience Translational Medicine
Volume8
Issue342
Start Page342ps13
Date Published06/2016
Abstract

The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

DOI10.1126/scitranslmed.aad2304
Short TitleScience Translational Medicine