Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

TitleCardiac fibroblasts in pressure overload hypertrophy: the enemy within?
Publication TypeJournal Article
Year of Publication2014
AuthorsBursac, N
JournalJournal of Clinical Investigation
Volume124
Issue7
Start Page2850
Pagination2850 - 2853
Date Published07/2014
Abstract

Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.

DOI10.1172/jci76628
Short TitleJournal of Clinical Investigation