Publications

2018

Khodabukus, Alastair, Neel Prabhu, Jason Wang, and Nenad Bursac. “In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.” Advanced Healthcare Materials 7, no. 15 (August 2018): e1701498. https://doi.org/10.1002/adhm.201701498.

Gokhale, Tanmay A., Huda Asfour, Shravan Verma, Nenad Bursac, and Craig S. Henriquez. “Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.” PLoS Computational Biology 14, no. 7 (July 2018): e1006276. https://doi.org/10.1371/journal.pcbi.1006276.

Nguyen, Hung X., Robert D. Kirkton, and Nenad Bursac. “Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies.” Nature Protocols 13, no. 5 (May 2018): 927–45. https://doi.org/10.1038/nprot.2018.016.

Chen, Y. -. H., C. -. H. Chou, A. Khodabukus, N. Bursac, G. Truskey, W. Kraus, and V. B. Kraus. “Effects of simulated muscle exercise on chondrocyte gene expression in a 3D-alginate bead model system.” In Osteoarthritis and Cartilage, 26:S139–40. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.303.

Jackman, Christopher P., Asvin M. Ganapathi, Huda Asfour, Ying Qian, Brian W. Allen, Yanzhen Li, and Nenad Bursac. “Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.” Biomaterials 159 (March 2018): 48–58. https://doi.org/10.1016/j.biomaterials.2018.01.002.

Koeberl, Dwight, Laura Case, Edward C. Smith, Yanzhen Li, Crista Walters, Christoph Hornik, Beth Thurberg, Deeksha Bali, Nenad Bursac, and Priya S. Kishnani. “Correction of biochemical abnormalities and gene expression associated with improved muscle function in a phase I/II clinical trial of clenbuterol in Pompe disease patients stably treated with ERT.” In Molecular Genetics and Metabolism, 123:S79–80. Elsevier BV, 2018. https://doi.org/10.1016/j.ymgme.2017.12.202.

Rao, Lingjun, Ying Qian, Alastair Khodabukus, Thomas Ribar, and Nenad Bursac. “Engineering human pluripotent stem cells into a functional skeletal muscle tissue.” Nature Communications 9, no. 1 (January 2018): 126. https://doi.org/10.1038/s41467-017-02636-4.

Pomeroy, Jordan E., and Nenad Bursac. “Selective Gq Activation in Cardiac Fibroblasts Decreases Isometric Force Generation in 3D Engineered Cardiac Tissues.” In CIRCULATION, Vol. 138, 2018.

2017

Khodabukus, A., L. Madden, C. Jackman, N. Prabhu, T. Koves, and N. Bursac. “Combined Drug and Electrical Stimulation Synergistically Increase Function of Engineered Human Skeletal Muscle.” In TISSUE ENGINEERING PART A, 23:S39–40. MARY ANN LIEBERT, INC, 2017.

Khodabukus, A., N. Prabhu, and N. Bursac. “Development of a Human Tissue-Engineered Model of Duchenne Muscular Dystrophy.” In TISSUE ENGINEERING PART A, 23:S115–S115. MARY ANN LIEBERT, INC, 2017.

Jackman, C. P., S. Heo, and N. Bursac. “Tissue-engineered Cardiobundles for In Vitro Development of Heart Regeneration Therapies.” In TISSUE ENGINEERING PART A, 23:S2–S2. MARY ANN LIEBERT, INC, 2017.

Li, Y., H. Asfour, L. Mao, H. A. Rockman, and N. Bursac. “3D Tissue-engineered Model of Pressure-overload Induced Cardiac Fibrosis.” In TISSUE ENGINEERING PART A, 23:S64–S64. MARY ANN LIEBERT, INC, 2017.

Rao, L., Y. Qian, A. Khodabukus, T. Ribar, and N. Bursac. “Contractile hPSC derived Skeletal Muscle Tissues for Human Disease Modeling.” In TISSUE ENGINEERING PART A, 23:S128–S128. MARY ANN LIEBERT, INC, 2017.

Juhas, M., N. O. Abutaleb, J. T. Wang, and N. Bursac. “Skeletal Muscle-Macrophage Platform for Modeling Tissue Regeneration.” In TISSUE ENGINEERING PART A, 23:S9–S9. MARY ANN LIEBERT, INC, 2017.

Wang, J., A. Khodabukus, M. Juhas, N. Abutaleb, and N. Bursac. “In Vitro Bioengineered Model for Studies of Human Muscle Regeneration.” In TISSUE ENGINEERING PART A, 23:S71–S71. MARY ANN LIEBERT, INC, 2017.

Shadrin, Ilya Y., Brian W. Allen, Ying Qian, Christopher P. Jackman, Aaron L. Carlson, Mark E. Juhas, and Nenad Bursac. “Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.” Nat Commun 8, no. 1 (November 28, 2017): 1825. https://doi.org/10.1038/s41467-017-01946-x.

Polstein, Lauren R., Mark Juhas, Gabi Hanna, Nenad Bursac, and Charles A. Gersbach. “An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis.” ACS Synthetic Biology 6, no. 11 (November 2017): 2003–13. https://doi.org/10.1021/acssynbio.7b00147.

Cao, Jingli, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, et al. “Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.” Dev Cell 42, no. 6 (September 25, 2017): 600-615.e4. https://doi.org/10.1016/j.devcel.2017.08.024.

Yanamandala, Mounica, Wuqiang Zhu, Daniel J. Garry, Timothy J. Kamp, Joshua M. Hare, Ho-Wook Jun, Young-Sup Yoon, et al. “Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.” Journal of the American College of Cardiology 70, no. 6 (August 2017): 766–75. https://doi.org/10.1016/j.jacc.2017.06.012.

Bassat, Elad, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin, Kfir Baruch Umansky, Oren Yifa, David Kain, et al. “The extracellular matrix protein agrin promotes heart regeneration in mice.” Nature 547, no. 7662 (July 2017): 179–84. https://doi.org/10.1038/nature22978.

Li, Yanzhen, Huda Asfour, and Nenad Bursac. “Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue.” Acta Biomaterialia 55 (June 2017): 120–30. https://doi.org/10.1016/j.actbio.2017.04.027.

Liau, Brian, Christopher P. Jackman, Yanzhen Li, and Nenad Bursac. “Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues.” Scientific Reports 7 (February 2017): 42290. https://doi.org/10.1038/srep42290.

Pomeroy, Jordan E., Hung X. Nguyen, Brenton D. Hoffman, and Nenad Bursac. “Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells.” Theranostics 7, no. 14 (2017): 3539–58. https://doi.org/10.7150/thno.20593.

Gokhale, Tanmay A., Jong M. Kim, Robert D. Kirkton, Nenad Bursac, and Craig S. Henriquez. “Modeling an Excitable Biosynthetic Tissue with Inherent Variability for Paired Computational-Experimental Studies.” PLoS Computational Biology 13, no. 1 (January 2017): e1005342. https://doi.org/10.1371/journal.pcbi.1005342.

2016

Li, Yanzhen, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Nenad Bursac, and Victor J. Dzau. “Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.” Sci Rep 6 (December 12, 2016): 38815. https://doi.org/10.1038/srep38815.