Publications

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Tianyu Wu, Abbigail Helfer, Jacob Scherba, et al. “Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium.” Science Advances 10, no. 4 (January 2024): eadh2598. https://doi.org/10.1126/sciadv.adh2598.

Fuchs, Michaela A., Emily J. Burke, Nejla Latic, Susan Murray, Hanjun Li, Matthew Sparks, Dennis Abraham, et al. “Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.” Res Sq, December 23, 2023. https://doi.org/10.21203/rs.3.rs-3705543/v1.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nat Commun 14, no. 1 (November 16, 2023): 7411. https://doi.org/10.1038/s41467-023-43260-9.

Needs, Daniel, Tianyu Wu, Hung X. Nguyen, Craig S. Henriquez, and Nenad Bursac. “Prokaryotic voltage-gated sodium channels are more effective than endogenous Na_v1.5 channels in rescuing cardiac action potential conduction: an in silico study.” American Journal of Physiology. Heart and Circulatory Physiology 325, no. 5 (November 2023): H1178–92. https://doi.org/10.1152/ajpheart.00287.2023.

Chakraborty, Archan, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, et al. “Conserved chamber-specific polyploidy maintains heart function in Drosophila.” Development 150, no. 16 (August 15, 2023). https://doi.org/10.1242/dev.201896.

Zhang, Qiao, Ren-Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen, Barbara D. Lipes, Nenad Bursac, and George A. Truskey. “Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID-19 Virus.” J Am Heart Assoc 12, no. 12 (June 20, 2023): e029390. https://doi.org/10.1161/JAHA.123.029390.

Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.

Lee, David E., Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, and James P. White. “Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.” Nat Commun 13, no. 1 (December 9, 2022): 7613. https://doi.org/10.1038/s41467-022-35390-3.

Scherba, Jacob C., Ravi Karra, Joseph W. Turek, and Nenad Bursac. “Toward improved understanding of cardiac development and congenital heart disease: The advent of cardiac organoids.” J Thorac Cardiovasc Surg 164, no. 6 (December 2022): 2013–18. https://doi.org/10.1016/j.jtcvs.2022.02.028.

Khodabukus, Alastair, Tyler Guyer, Axel C. Moore, Molly M. Stevens, Robert E. Guldberg, and Nenad Bursac. “Translating musculoskeletal bioengineering into tissue regeneration therapies.” Science Translational Medicine 14, no. 666 (October 2022): eabn9074. https://doi.org/10.1126/scitranslmed.abn9074.

Scherba, Jacob C., Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, and Carolyn Glass. “BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.” Sci Rep 12, no. 1 (May 17, 2022): 7996. https://doi.org/10.1038/s41598-022-11829-x.

Wang, Jason, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran, Yu Xiang, Alastair Khodabukus, Yarui Diao, and Nenad Bursac. “Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.” Biomaterials 284 (May 2022): 121508. https://doi.org/10.1016/j.biomaterials.2022.121508.

Nguyen, Hung X., Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, et al. “Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.” Nature Communications 13, no. 1 (February 2022): 620. https://doi.org/10.1038/s41467-022-28251-6.

Janbandhu, Vaibhao, Vikram Tallapragada, Ralph Patrick, Yanzhen Li, Dhanushi Abeygunawardena, David T. Humphreys, Ella M. M. A. Martin, et al. “Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.” Cell Stem Cell 29, no. 2 (February 2022): 281-297.e12. https://doi.org/10.1016/j.stem.2021.10.009.

Vann, Christopher G., Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu-Hsiu Chen, David L. Corcoran, George A. Truskey, Nenad Bursac, and Virginia B. Kraus. “Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle.” Front Physiol 13 (2022): 937899. https://doi.org/10.3389/fphys.2022.937899.

Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.

Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Yifan Chen, Jacob Scherba, Mehul Jain, Ramona Naseri, Tianyu Wu, and Nenad Bursac. “BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.28.482357.

DeLuca, Sophia, and Nenad Bursac. “CRISPR Library Screening in Cultured Cardiomyocytes.” Methods in Molecular Biology (Clifton, N.J.) 2485 (January 2022): 1–13. https://doi.org/10.1007/978-1-0716-2261-2_1.

Strash, Nicholas, Sophia DeLuca, Geovanni L. Janer Carattini, Soon Chul Heo, Ryne Gorsuch, and Nenad Bursac. “Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.” ELife 10 (October 2021): e65512. https://doi.org/10.7554/elife.65512.

Ransey, Elizabeth, Kirill Chesnov, Nenad Bursac, and Kafui Dzirasa. “FETCH: A platform for high-throughput quantification of gap junction hemichannel docking.” Cold Spring Harbor Laboratory, June 7, 2021. https://doi.org/10.1101/2021.06.07.447352.

Wang, Jason, Chris J. Zhou, Alastair Khodabukus, Sabrina Tran, Sang-Oh Han, Aaron L. Carlson, Lauran Madden, Priya S. Kishnani, Dwight D. Koeberl, and Nenad Bursac. “Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease.” Commun Biol 4, no. 1 (May 5, 2021): 524. https://doi.org/10.1038/s42003-021-02059-4.

Zhan, Ren-Zhi, Lingjun Rao, Zhaowei Chen, Nicholas Strash, and Nenad Bursac. “Loss of sarcomeric proteins via upregulation of JAK/STAT signaling underlies interferon-γ-induced contractile deficit in engineered human myocardium.” Acta Biomaterialia 126 (May 2021): 144–53. https://doi.org/10.1016/j.actbio.2021.03.007.

Saha, Krishanu, Erik J. Sontheimer, P. J. Brooks, Melinda R. Dwinell, Charles A. Gersbach, David R. Liu, Stephen A. Murray, et al. “The NIH Somatic Cell Genome Editing program.” Nature 592, no. 7853 (April 2021): 195–204. https://doi.org/10.1038/s41586-021-03191-1.

Wu, Tianyu, Hung X. Nguyen, and Nenad Bursac. “In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy.,” 654:407–34, 2021. https://doi.org/10.1016/bs.mie.2021.03.008.

Chen, Zhaowei, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, and Nenad Bursac. “Exercise mimetics and JAK inhibition attenuate IFN-γ-induced wasting in engineered human skeletal muscle.” Science Advances 7, no. 4 (January 2021): eabd9502. https://doi.org/10.1126/sciadv.abd9502.