Publications

Chen, Zhaowei, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, and Nenad Bursac. “Exercise mimetics and JAK inhibition attenuate IFN-γ-induced wasting in engineered human skeletal muscle.” Science Advances 7, no. 4 (January 2021): eabd9502. https://doi.org/10.1126/sciadv.abd9502.

Helfer, Abbigail, and Nenad Bursac. “Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs.” Methods in Molecular Biology (Clifton, N.J.) 2158 (January 2021): 171–86. https://doi.org/10.1007/978-1-0716-0668-1_13.

Fralish, Zachary, Ethan M. Lotz, Taylor Chavez, Alastair Khodabukus, and Nenad Bursac. “Neuromuscular Development and Disease: Learning From in vitro and in vivo Models.” Frontiers in Cell and Developmental Biology 9 (January 2021): 764732. https://doi.org/10.3389/fcell.2021.764732.

Kondash, Megan E., Anandita Ananthakumar, Alastair Khodabukus, Nenad Bursac, and George A. Truskey. “Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle.” Tissue Engineering and Regenerative Medicine 17, no. 6 (December 2020): 801–13. https://doi.org/10.1007/s13770-020-00242-y.

Khodabukus, Alastair, Amulya Kaza, Jason Wang, Neel Prabhu, Richard Goldstein, Vishal S. Vaidya, and Nenad Bursac. “Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers.” Toxicological Sciences : An Official Journal of the Society of Toxicology 176, no. 1 (July 2020): 124–36. https://doi.org/10.1093/toxsci/kfaa049.

Broer, Torie, Alastair Khodabukus, and Nenad Bursac. “Can we mimic skeletal muscles for novel drug discovery?” Expert Opinion on Drug Discovery 15, no. 6 (June 2020): 643–45. https://doi.org/10.1080/17460441.2020.1736031.

Li, Yanzhen, Daniel Song, Lan Mao, Dennis M. Abraham, and Nenad Bursac. “Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure.” Biomaterials 236 (April 2020): 119824. https://doi.org/10.1016/j.biomaterials.2020.119824.

Pomeroy, Jordan E., Abbigail Helfer, and Nenad Bursac. “Biomaterializing the promise of cardiac tissue engineering.” Biotechnol Adv 42 (2020): 107353. https://doi.org/10.1016/j.biotechadv.2019.02.009.

Sklivas, Alexander Byron, Dante I. I. Goss, Nenad Bursac, Alastair Khodahukus, Tim Koves, Deborah Muoio, Lauran Madden, George A. Truskey, William E. Kraus, and Monica J. Hubal. “Gene Expression Differences In Three-dimensional Myobundles Compared To Two-dimensional Myocultures.” In MEDICINE & SCIENCE IN SPORTS & EXERCISE, 52:781–82, 2020.

Strash, Nicholas, Sophia DeLuca, Geovanni Janer Carattini, Soon Chul Heo, Ryne Gorsuch, and Nenad Bursac. “Human Erbb2-induced Erk Activity Robustly Stimulates Cycling and Functional Remodeling of Rat and Human Cardiomyocytes.” BioRxiv, 2020. https://doi.org/10.1101/2020.12.15.422603.

Wang, Jason, Alastair Khodabukus, Lingjun Rao, Keith Vandusen, Nadia Abutaleb, and Nenad Bursac. “Engineered skeletal muscles for disease modeling and drug discovery.” Biomaterials 221 (November 2019): 119416. https://doi.org/10.1016/j.biomaterials.2019.119416.

Yifa, Oren, Karen Weisinger, Elad Bassat, Hanjun Li, David Kain, Haim Barr, Noga Kozer, et al. “The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice.” JCI Insight 4, no. 22 (November 2019): 128025. https://doi.org/10.1172/jci.insight.128025.

Sengupta, Swarnali, Katheryn E. Rothenberg, Hanjun Li, Brenton D. Hoffman, and Nenad Bursac. “Altering integrin engagement regulates membrane localization of K_ir2.1 channels.” Journal of Cell Science 132, no. 17 (September 2019): jcs225383. https://doi.org/10.1242/jcs.225383.

Nguyen, Hung X., and Nenad Bursac. “Ion channel engineering for modulation and de novo generation of electrical excitability.” Current Opinion in Biotechnology 58 (August 2019): 100–107. https://doi.org/10.1016/j.copbio.2019.01.004.

Khodabukus, Alastair, Lauran Madden, Neel K. Prabhu, Timothy R. Koves, Christopher P. Jackman, Deborah M. Muoio, and Nenad Bursac. “Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.” Biomaterials 198 (April 2019): 259–69. https://doi.org/10.1016/j.biomaterials.2018.08.058.

Berry, Joel L., Wuqiang Zhu, Yao Liang Tang, Prasanna Krishnamurthy, Ying Ge, John P. Cooke, Yabing Chen, et al. “Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.” Circ Res 124, no. 1 (January 4, 2019): 161–69. https://doi.org/10.1161/CIRCRESAHA.118.314216.

Juhas, Mark, Nadia Abutaleb, Jason T. Wang, Jean Ye, Zohaib Shaikh, Chaichontat Sriworarat, Ying Qian, and Nenad Bursac. “Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.” Nature Biomedical Engineering 2, no. 12 (December 2018): 942–54. https://doi.org/10.1038/s41551-018-0290-2.

Koeberl, Dwight D., Laura E. Case, Edward C. Smith, Crista Walters, Sang-Oh Han, Yanzhen Li, Wei Chen, et al. “Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.” Mol Ther 26, no. 9 (September 5, 2018): 2304–14. https://doi.org/10.1016/j.ymthe.2018.06.023.

Jackman, Christopher, Hanjun Li, and Nenad Bursac. “Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function.” Acta Biomaterialia 78 (September 2018): 98–110. https://doi.org/10.1016/j.actbio.2018.08.003.

Khodabukus, Alastair, Neel Prabhu, Jason Wang, and Nenad Bursac. “In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.” Advanced Healthcare Materials 7, no. 15 (August 2018): e1701498. https://doi.org/10.1002/adhm.201701498.

Gokhale, Tanmay A., Huda Asfour, Shravan Verma, Nenad Bursac, and Craig S. Henriquez. “Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.” PLoS Computational Biology 14, no. 7 (July 2018): e1006276. https://doi.org/10.1371/journal.pcbi.1006276.

Nguyen, Hung X., Robert D. Kirkton, and Nenad Bursac. “Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies.” Nature Protocols 13, no. 5 (May 2018): 927–45. https://doi.org/10.1038/nprot.2018.016.

Chen, Y. -. H., C. -. H. Chou, A. Khodabukus, N. Bursac, G. Truskey, W. Kraus, and V. B. Kraus. “Effects of simulated muscle exercise on chondrocyte gene expression in a 3D-alginate bead model system.” In Osteoarthritis and Cartilage, 26:S139–40. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.303.

Jackman, Christopher P., Asvin M. Ganapathi, Huda Asfour, Ying Qian, Brian W. Allen, Yanzhen Li, and Nenad Bursac. “Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.” Biomaterials 159 (March 2018): 48–58. https://doi.org/10.1016/j.biomaterials.2018.01.002.

Koeberl, Dwight, Laura Case, Edward C. Smith, Yanzhen Li, Crista Walters, Christoph Hornik, Beth Thurberg, Deeksha Bali, Nenad Bursac, and Priya S. Kishnani. “Correction of biochemical abnormalities and gene expression associated with improved muscle function in a phase I/II clinical trial of clenbuterol in Pompe disease patients stably treated with ERT.” In Molecular Genetics and Metabolism, 123:S79–80. Elsevier BV, 2018. https://doi.org/10.1016/j.ymgme.2017.12.202.