System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors.

TitleSystem identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors.
Publication TypeJournal Article
Year of Publication2001
AuthorsAljuri, AN, Bursac, N, Marini, R, and Cohen, RJ
JournalActa Astronautica
Volume49
Issue3-10
Start Page167
Pagination167 - 170
Date Published08/2001
Abstract

Prolonged exposure to microgravity in space flight missions (days) impairs the mechanisms responsible for defense of arterial blood pressure (ABP) and cardiac output (CO) against orthostatic stress in the post-flight period. The mechanisms responsible for the observed orthostatic intolerance are not yet completely understood. Additionally, effective counter measures to attenuate this pathophysiological response are not available. The aim of this study was to investigate the ability of our proposed system identification method to predict closed-loop dynamic changes in TPR induced by changes in mean arterial pressure (MAP) and right atrial pressure (RAP). For this purpose we designed and employed a novel experimental animal model for the examination of arterial and cardiopulmonary baroreceptors in the dynamic closed-loop control of total peripheral resistance (TPR), and applied system identification to the analysis of beat-to-beat fluctuations in the measured signals. Grant numbers: NAG5-4989.

Short TitleActa Astronautica