Engineering skeletal muscle repair

TitleEngineering skeletal muscle repair
Publication TypeJournal Article
Year of Publication2013
AuthorsM Juhas, and N Bursac
JournalCurrent Opinion in Biotechnology
Volume24
Issue5
Start Page880
Pagination880 - 886
Date Published01/2013
Abstract

Healthy skeletal muscle has a remarkable capacity for regeneration. Even at a mature age, muscle tissue can undergo a robust rebuilding process that involves the formation of new muscle cells and extracellular matrix and the re-establishment of vascular and neural networks. Understanding and reverse-engineering components of this process is essential for our ability to restore loss of muscle mass and function in cases where the natural ability of muscle for self-repair is exhausted or impaired. In this article, we will describe current approaches to restore the function of diseased or injured muscle through combined use of myogenic stem cells, biomaterials, and functional tissue-engineered muscle. Furthermore, we will discuss possibilities for expanding the future use of human cell sources toward the development of cell-based clinical therapies and in vitro models of human muscle disease. © 2013 Elsevier Ltd.

DOI10.1016/j.copbio.2013.04.013
Short TitleCurrent Opinion in Biotechnology