Yanzhen Li

Li

My research is focused on the field of cardiovascular disease and cardiac tissue engineering. An important component of my current thesis research is to better understand the complex bidirectional cardiomyocyte-fibroblast interactions potentially involving complex bidirectional signaling through direct cell-cell contacts, paracrine actions, and/or extracellular matrix-mediated effects. I have been combining the use of diseased mouse models and tissue engineering techniques to systematically assess how disease-induced changes in fibroblast phenotype alter the electrical and mechanical function of cardiomyocyte in vitro and determine the underlying molecular mechanisms. Through this and future studies, I hope to discover novel fibroblast-related targets leading to more efficient drug or gene therapies for heart disease.

Contact Information:

  • Email Address: yanzhen.li@duke.edu

Research Interests:

I am studying how disease-induced changes in fibroblast phenotype alter the electrical and mechanical function of 3D engineered cardiac tissues and determine the underlying molecular mechanisms.